A patient is administered imipenem–cilastatin for the treatment of an E. coli infection. The nurse should be aware that cilastatin is combined with the imipenem for what purpose?
A) To eliminate adverse effects of imipenem administration
B) To inhibit the destruction of imipenem
C) To potentiate the therapeutic effects of imipenem
D) To allow imipenem to cross the blood–brain barrier
B
Feedback:
Cilastatin inhibits the destruction of imipenem, increasing the urinary concentration of imipenem and reducing its potential renal toxicity. It does not allow the drug to cross the blood–brain barrier, and cilastatin does not eliminate all adverse effects.
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