The pathologic effects of the thalassemias are primarily due to which of the following pathophysiologic processes?
A) Impaired hemoglobin synthesis
B) Impaired folic acid absorption
C) Erythropoietin deficiency
D) Loss of iron
Ans: A
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The thalassemias are a heterogeneous group of inherited disorders caused by mutations that decrease the rate of ?- or ?-globin chains. The pathologic effects of the thalassemias are not direct results of impaired folic acid absorption or a lack of erythropoietin or iron.
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