Why do COX-2 inhibitors increase the risk for cardiovascular problems? (Select all that apply.)
A) Vasoconstriction is blocked.
B) Vasodilation is blocked.
C) Platelet clumping is blocked.
D) Water and sodium balance is altered.
E) Gastrointestinal (GI) integrity is altered.
B, C
Feedback:
Recent studies suggest that COX-2 inhibitors may block some protective responses in the body, such as vasodilation and inhibited platelet clumping, which is protective if vessel narrowing or blockage occurs. Blocking this effect could lead to cardiovascular problems. Vasoconstriction is not blocked, water and sodium balance is not altered, and GI integrity is not impacted by COX-2 inhibitors but can be impacted by COX-1 inhibitors.
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