Discuss how the feedback mechanism for iron absorption is altered in iron-deficiency anemia.

What will be an ideal response?


Persons with uncomplicated deficiencies of iron already have upregulated proteins for enhancing iron absorption from the digestive tract. One such protein (hepcidin) communicates iron status and erythropoietic demands to the small intestine and modulates absorption. This feedback mechanism allows deficient individuals to enhance their absorption of available heme and non-heme iron. Iron-deficiency anemia can be corrected through continued iron-dense, nutrient-dense dietary intake, supplementation, and correction of any underlying conditions that may be contributing to the deficit. Increasing the nutrient density of foods over the long term is the best strategy.

Nutritional Science

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