Which of the following is the most important protease of the coagulation pathway because of its role in so many different catalytic functions?
a. Thrombin
b. Factor XIa
c. Plasmin
d. Factor VIIa
ANS: A
Thrombin is considered the most important protease of the coagulation pathway because of its multiple functions. These include splitting fibrinogen to form fibrin monomers; activating the cofactors V and VIII; activating factor XIII; binding to thrombomodulin to activate protein C; and aggregating platelets, to name just a few.
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