The nurse caring for a client with a dysrhythmia understands the effects of which antidysrhythmic drug can last 4–8 weeks after the drug is discontinued because it has an extended half-life that can exceed 50 days?
1. Digoxin (Lanoxin)
2. Verapamil (Calan)
3. Propranolol (Inderal)
4. Amiodarone (Cordarone)
4
Rationale 1:Digoxin (Lanoxin) is incorrect because amiodarone can last 4–8 weeks after the drug is discontinued because it has an extended half-life that can exceed 100 days.
Rationale 2:Verapamil (Calan) is incorrect because amiodarone can last 4–8 weeks after the drug is discontinued because it has an extended half-life that can exceed 100 days.
Rationale 3:Propranolol (Inderal) is incorrect because amiodarone can last 4–8 weeks after the drug is discontinued because it has an extended half-life that can exceed 100 days.
Rationale 4: Amiodarone is available as oral tablets and as an IV infusion. IV infusions are limited to short-term therapy, normally only 2–4 days. Its onset of action can take several weeks when the drug is given orally. Its effects, however, can last 4–8 weeks after the drug is discontinued because it has an extended half-life that can exceed 50 days.
Global Rationale: Amiodarone is available as oral tablets and as an IV infusion. IV infusions are limited to short-term therapy, normally only 2–4 days. Its onset of action can take several weeks when the drug is given orally. Its effects, however, can last 4–8 weeks after the drug is discontinued because it has an extended half-life that can exceed 100 days.
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