A nurse is teaching a group of nursing students about irreversible cholinesterase inhibitors. Which statement by a student indicates understanding of the teaching?
a. "Diazepam is given to reverse inhibition of cholinesterase when overdose occurs."
b. "Irreversible cholinesterase inhibitors are rapidly absorbed by all routes."
c. "These agents are often used to treat glaucoma."
d. "Toxic doses of these agents produce an anticholinergic crisis."
ANS: B
Almost all of these agents are highly lipid soluble, making them readily absorbed from all routes of administration. Diazepam is used during overdose but only to control seizures and not to reverse effects. The only clinical use for these agents is to treat glaucoma, but this use is limited. Toxic doses of these agents produce a cholinergic, not an anticholinergic, crisis.
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