For each feature of self-tolerance described in questions 4-10, choose the term (letters A-K) that most closely matches it

A. Immature (IgM+IgD?)
B. Thymic cortex
C. Bone marrow
D. Antigen recognition without T cell help
E. Receptor editing
F. Activation-induced cell death
G. Regulatory T cell-mediated suppression
H. Antigen recognition with costimulation
I. Double positive (CD4+CD8+)
J. Anergy
K. Thymic medulla

Tolerance-sensitive stage of T cell maturation


ANS: I. Central T cell tolerance is induced largely by clonal deletion (negative selection) in the thymus at the CD4+CD8+ stage of T cell maturation.

Health & Biomechanics

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