Which of the following is true about spongiform encephalopathies?
A) The disease is tied to a normal cellular prion protein (PrPC) that is found mostly on the surface of neurons.
B) Spongiform encephalopathies occur in a wide variety of mammals, but the infectious prions are species specific and do not cause disease in other species.
C) Abnormal prions clump together and kill the affected neurons, which accounts for the spongelike appearance of brain tissue found in TSE autopsies.
D) When the normal prion protein encounters an abnormally shaped version of itself, PrPSC, the normal prion's shape is changed and it becomes an infectious PrPSC.
E) Spontaneous cases of Creuztfeldt-Jakob disease may be caused by mutations during cell division in neuronal stem cells.
Answer: B
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