The nurse is reviewing medications that have been proven effective for weight loss. Which medications does the nurse identify as being removed from the market due to safety concerns?
Standard Text: Select all that apply.
1. Amphetamine and dextroamphetamine (Dexedrine)
2. Orlistat (Alli)
3. Fenfluramine and phentermine (Fen-Phen)
4. Ephedra alkaloids
5. Sibutramine (Meridia)
Correct Answer: 3,4,5
Rationale 1: Although these medications are highly addictive and rarely prescribed for weight loss, they have not been pulled from the market due to safety issues.
Rationale 2: Orlistat (Alli) is an over-the-counter (OTC) medication that is still available for use to aide a weight-loss program.
Rationale 3: Fenfluramine was removed from the market for causing heart valve defects.
Rationale 4: Ephedra alkaloids have been removed from the market due to an increased incidence of adverse cardiovascular events.
Rationale 5: Sibutramine (Meridia) was voluntarily withdrawn from the U.S. market due to an increased risk of heart attacks and strokes.
Global Rationale: Fenfluramine was removed from the market for causing heart valve defects. Ephedra alkaloids have been removed from the market due to an increased incidence of adverse cardiovascular events. Sibutramine (Meridia) was voluntarily withdrawn from the U.S. market due to an increased risk of heart attacks and strokes. Although these medications are highly addictive and rarely prescribed for weight loss, they have not been pulled from the market due to safety issues. Orlistat (Alli) is an over-the-counter (OTC) medication that is still available for use to aide a weight-loss program
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