When a patient presents at the emergency department for an allergic reaction, the nurse recogniz-es the most severe consequence of a type I hypersensitivity reaction is:
a. urticaria.
b. hives.
c. anaphylaxis.
d. antibody-dependent cell-mediated cyto-toxicity (ADCC).
ANS: C
The most rapid and severe immediate hypersensitivity type I reaction is anaphylaxis. Urticaria, or hives, is a dermal (skin) manifestation of allergic reactions. Hives and urticaria are similar re-sponses. ADCC is a mechanism that involves natural killer (NK) cells. Antibodies on the target cell are recognized by Fc receptors on the NK cells, which release toxic substances that destroy the target cell.
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