Explain how genetic deficiencies of early complement components are associated with

immune complex and autoimmune disorders such as systemic lupus erythematosus.

What will be an ideal response


Complement plays a role in the recognition and clearance of immune complexes, as well as dead host tissue. Lack
of early complement components that are key in recognizing that an antigen/antibody reaction has occurred will
result in an increased life span of circulating immune complexes. Further, if dead host cells are not cleared
efficiently, there is increased exposure time of their antigens to the immune system and an increased risk of
autoimmunity.

Health & Biomechanics

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