Which of the following is most useful for considering the diagnosis of bone marrow failure?

a. A hemoglobin concentration of 11 g/dL
b. An absolute neutrophil count of less than 0.5 ยด 103/dL
c. A hypercellular bone marrow
d. Abnormal platelet function tests


ANS: B
An absolute neutrophil count of less than 0.5 ´ 103/dL is found in severe aplastic anemia, although it is not specific for this. The bone marrow will be hypocellular, not hypercellular. A mild anemia of 11 g/dL is found in many different conditions, and platelet function tests are not useful in diagnosing bone marrow failure.

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