The patient is receiving diltiazem (Cardizem) and wants to know why he developed a headache after taking the medication. What is the best response by the nurse?
1. "Diltiazem (Cardizem) causes the blood vessels in your brain to widen; giving you the headache."
2. "Diltiazem (Cardizem) increases prostaglandin synthesis; giving you the headache."
3. "Diltiazem (Cardizem) releases Substance P, activating pain receptors in your brain and giving you the headache."
4. "Diltiazem (Cardizem) causes the blood vessels in your brain to narrow; giving you the headache."
Correct Answer: 1
Rationale: Side effects of diltiazem (Cardizem) are generally not serious and are related to vasodilation: headache, dizziness, and edema of the ankles and feet. Side effects of diltiazem (Cardizem) are related to vasodilation, not vasoconstriction. Diltiazem (Cardizem) does not alter prostaglandin synthesis. Diltiazem (Cardizem) does not lead to a release of Substance P.
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