A patient's recent symptoms of unexplained fatigue and listlessness have prompted a referral to the endocrinology department. A plasma corticotropin (ACTH) stimulation test for adrenal insufficiency is being performed
Following the administration of ACTH, what finding would confirm the suspected diagnosis? A) Low cortisol levels
B) Stupor
C) Increased levels of CRH
D) Signs of Cushing's disease
A
Feedback:
Confirming the diagnosis of adrenocortical insufficiency requires a short plasma corticotropin (ACTH) stimulation test. The examiner administers corticotropin in the morning, and a subnormal blood cortisol level in the morning and afternoon confirms the diagnosis. CRH is a precursor to ACTH, and would not be directly affected. Cushing's disease is adrenocortical excess, with high cortisol levels.
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