Which of the following pathogenetic mechanisms plays a role in the pathogenesis of fatty liver caused by chronic alcohol abuse?
A. increased influx of free fatty acids into the liver
B. decreased esterification of free fatty acids to triglycerides in the liver
C. increased oxidation of free fatty acids
D. increased production of lipoproteins
E. increased degradation of hepatic triglycerides
A
Alcohol leads to increased hepatic influx of free fatty acids (FFAs) from peripheral stores. Alcohol also causes increased intrahepatic esterification of FFAs to triglycerides, decreased oxidation of FFAs, and because of protein malnutrition it reduces the export of lipids in the form of lipoproteins.
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