Which of the following is most responsible for the strength and pliancy of the red cell membrane?
a. Glycophorin A
b. Spectrin
c. Cholesterol
d. Ankyrin
ANS: B
Spectrin composes 50% to 70% of the membrane skeletal mass and is the primary peripheral protein involved in maintaining the skeletal structure of the red cell. By the way it lines up with other spectrin molecules, it also plays an important role in making the red cell membrane deformable (pliant). This flexibility is important for permitting the red cell to "squeeze" through pores that have a diameter smaller than that of the red cell.
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