When doxacurium (a long-acting, nondepolarizing neuromuscular blocker) is given, the nurse can expect prolonged muscle relaxation in clients with which condition?
1. Hepatitis
2. Heart failure
3. Renal insufficiency
4. Chronic obstructive pulmonary disease
Correct Answer: 3
Rationale 1: Hepatitis would not affect duration of drug action.
Rationale 2: Heart failure would not affect duration of drug action.
Rationale 3: Renal insufficiency will increase the time required to clear this drug from the body, leading to a prolonged drug effect.
Rationale 4: Chronic obstructive pulmonary disease would not affect duration of drug action.
Global Rationale: Renal insufficiency will increase the time required to clear this drug from the body, leading to a prolonged drug effect. Hepatitis, heart failure, and chronic obstructive pulmonary disease would not affect duration of drug action.
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Fill in the blank(s) with correct word
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