Protein binding
a. Refers to the time required for half the medication to be excreted or inactivated
b. Refers to the capacity of proteins in the bloodstream to be binding sites for drugs
c. Is how medications move into and through the body
d. Refers to the effect of specific medications at the site of action
B
Response A is the definition of half-life. Response C is the definition of pharmacokinetics. Response D is the definition for pharmacodynamics. Response B is correct; proteins are the binding sites for drugs. The percentage of medication that binds to a protein is inactive. Only a free drug is active to have the desired effect. Not all drugs are protein bound, but if a patient is taking two drugs that are, they are competing for the same number of sites. There is an increased percentage of free drug in the bloodstream. In this scenario, there is an increased impact on the effects and possible adverse effects of both drugs.
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