A nurse is providing teaching to a group of patients who are beginning drug therapy for acquired immunodeficiency syndrome (AIDS). What should be included in her instructions to the group?
A) "Take your medications as directed. Poisoning occurs with overdosage causing damage to more than one body system."
B) "Renal injury results from first-pass effect when the drug is excreted from the system."
C) "A blood dyscrasia due to drug therapy can be serious. Call us if your skin looks yellowish or you experience itching."
D) "Most drugs are metabolized in the liver and the first indication of damage is dark red papules, which should be reported immediately."
A
Feedback:
Poisoning resulting from overdosage can lead to the potential for fatal reactions when more than one body system is affected. Liver, not kidney, injury can be caused by the first-pass effect and can cause the skin to have a yellow appearance. Most drugs are metabolized in the liver but liver damage causes jaundice, manifested as a yellow tinge to the skin and sclera. Dark red papules appearing on limbs are characteristic of Stevens-Johnson syndrome, a potentially fatal erythema multiforme exudativum, which should be reported but is not due to liver damage.
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