Patients who have type 2 diabetes no longer express genes when exposed to insulin. How might this phenomenon be explained?
A. Insulin can no longer bind to the insulin receptor because the receptor is mutated.
B. The nucleus of their cells are altered so that insulin can not bind.
C. Transcription factors normally activated by insulin remain off.
D. The signal transduction pathways in the cells no longer exist.
E. The insulin signal transduction pathway becomes permanently activated.
Answer: C
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