Exogenous pyrogens (interleukin-1) and the presence of bacteria in the blood lead to the release of endogenous pyrogens that:
A) Stabilize thermal control in the brain
B) Produce leukocytosis and shivering
C) Block viral replication in cells
D) Inhibit prostaglandin release
Ans: B
Feedback:
Exogenous pyrogens induce host cells, such as blood leukocytes and tissue macrophages, to produce fever-producing mediators called endogenous pyrogens (e.g., IL-1). For example, the breakdown products of phagocytosed bacteria that are present in the blood lead to the release of endogenous pyrogens. The endogenous pyrogens are thought to increase the set point of the hypothalamic thermoregulatory center through the action of prostaglandin E2 (PGE2). In response to the sudden increase in set point, the hypothalamus initiates heat production behaviors (shivering and vasoconstriction) that increase the core body temperature to the new set point, and fever is established. Pyrogens are not capable of blocking viral replication or prostaglandin release.
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