A patient taking clozapine (Clozaril) says, "I get plenty of vitamin C by drinking 8 ounces of grapefruit juice each morning." Select the nurse's best response
a. "High doses of Vitamin C support the immune system and general good health."
b. "Name another juice you would drink, because grapefruit juice can cause a bad reaction while taking clozapine."
c. "Grapefruit juice lessens the effectiveness of your medication. You might need higher doses."
d. "New research shows papaya juice is a better source of vitamin C than grapefruit juice."
B
Only the correct option provides vital information based on the cytochrome P-450 enzyme system's involvement in drug metabolism. Clozapine metabolism is inhibited by the ingestion of grapefruit juice, making the likelihood of a toxic reaction to the drug more likely, because the drug accumulates in the body.
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