Which statements about the differences between first- and fourth-generation cephalosporins are correct? (Select all that apply.)
a. Fourth-generation agents have more activity against gram-negative organisms.
b. First-generation agents are more active against anaerobes.
c. First-generation agents have increased resistance to beta-lactamases.
d. Fourth-generation agents have an increased ability to reach the cerebrospinal fluid.
e. First-generation agents are more vulnerable to destruction by beta-lactamases.
ANS: A, D, E
Fourth-generation agents have more activity against gram-negative organisms and have an increased ability to reach the cerebrospinal fluid. First-generation agents are more vulnerable to destruction by beta-lactamases.
First-generation agents are not more active against anaerobes, nor do they have increased resistance to beta-lactamases.
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