What information would the nurse educator include when explaining how mosaicism occurs?
Note: Credit will be given only if all correct choices and no incorrect choices are selected.
Standard Text: Select all that apply.
1. Generalized mosaicism is more likely if the nondisjunction mistake happens in the first one or two divisions of the fertilized egg.
2. The type of cells involved in mosaicism is critical to the effects it will cause.
3. The effects of mosaicism are reduced if trisomic cells do not survive.
4. Earlier diagnosis of mosaicism will reduce the somatic effects.
5. Mosaicism affects cells only during meiotic division.
1,2,3
Rationale 1: If the nondisjunction occurs after the egg is fertilized and starting to divide, new cells are produced that will be part of the tissues. This results in a more generalized effect than if only the egg or sperm is involved.
Rationale 2: If the involved cells are critical to the function of an organ or tissue, the effects will be greater.
Rationale 3: The effects of mosaicism are related to the trisomic state of cells. If these cells die, there is no effect.
Rationale 4: There is currently nothing that can be done to "fix" the cells once they are affected. Diagnosis is often achieved only after the fetus is in the late first or second trimester or after the baby is born.
Rationale 5: Cells can become mosaic in both meiosis and mitosis.
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