In the microdilution broth dilution method, the interpretive criteria for the susceptible, interme-diate, or resistant categories are based on the:

a. quantitative differences (i.e., CFU/mL) in the turbidity in the test well.
b. correlation of the MIC with se-rum-achievable levels of the common doses of the antimicrobial agent and the-rapeutic outcomes based on clinical stu-dies.
c. either the presence or absence of zones of inhibition.
d. FDA's recommendations based on a na-tional database of participating health care agencies providing antibiograms for re-view and publication as a summative re-port.


B
The interpretive categories of MIC-based testing are defined according to the attainable concen-trations of the antibiotic in the patient's bloodstream. For the antibiotic to be effective, the con-centration of the drug in the serum must be inhibitory to the bacteria.

Biology & Microbiology

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