When describing the anticonvulsants to a group of nursing students, the instructor describes which of the following as acting to stabilize the hyperexcitability postsynaptically in the motor cortex of the brain? Select all that apply
A) Ethosuximide (Zarontin)
B) Phenytoin (Dilantin)
C) Valproic acid (Depakote)
D) Ethotoin (Peganone).
E) Topiramate (Topamax)
Ans: B, D
Feedback:
Hydantoins, like phenytoin (Dilantin) and ethotoin (Peganone), exert their effect by stabilizing the hyperexcitability postsynaptically in the motor cortex of the brain. Ethosuximide depresses the motor cortex, valproic acid increases levels of GABA to stabilize the cell membranes, and topiramate blocks seizure activity instead of raising the threshold.
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