All of the following pairs of an anticancer drug and a mechanism that has been shown to contribute to resistance to that drug are accurate EXCEPT:
A. Bleomycin: mutation in thymidylate synthase
B. Cisplatin: increased activity of proteins involved in DNA repair
C. Methotrexate: increased expression of DHFR
D. Paclitaxel: increased expression of P-glycoprotein MDR
E. Tamoxifen: reduced synthesis of estrogen receptors
Answer: A. Bleomycin: mutation in thymidylate synthase
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