Following carrier testing, it is determined that both the husband and wife have sickle-cell trait. Which statement by the wife indicates correct understanding of autosomal recessive inheritance?
1. "Because both my husband and I carry the trait but do not have the disease, I don't need to have prenatal testing because my baby will also be a carrier."
2. "Because both my husband and I are both carriers, I don't need to have prenatal testing because all of our children will have the disease.
3. "When I become pregnant, I need to have an amniocentesis or other prenatal test to determine whether my baby is affected with sickle-cell disease."
4. "There is no use undergoing prenatal testing as sickle-cell anemia cannot be diagnosed prenatally."
3
Rationale 1: The pregnant woman will require prenatal testing as her child will have a 50-50 chance of being a carrier and a 1 in 4 chance of being affected.
Rationale 2: Each child has a 50% chance of carrying the trait and a 25% chance of having the disorder.
Rationale 3: This statement is accurate.
Rationale 4: This statement is inaccurate because sickle-cell anemia can be diagnosed prenatally.
Global Rationale:
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