A nurse is preparing to administer a drug to a patient. The nurse understands that the route by which bioavailability would most likely be affected is
a. oral.
b. subcutaneous.
c. intramuscular.
d. intravenous.
ANS: A
Oral drugs must undergo a first-pass effect, and those drugs are subject to the acid in the gut, which may affect bioavailability.
Subcutaneous, intramuscular, and intravenous medications are not subject to the first-pass effect or the acidity of the gut, therefore bioavailability is least likely to be affected by these routes.
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