Why would an O/Rh-negative mother who gives birth to a baby who is B/Rh-positive be at less risk for developing anti-Rh antibodies than an O/Rh-negative mother who gives birth to an O/Rh-positive baby?

What will be an ideal response?


An Rh-negative mother may become sensitized to the Rh-positive antigen after delivering an Rh-positive child. This happens when the child's blood cells enter her circulation, and the Rh-positive antigen is sensed by the immune system and B cells begin to produce antibodies against it. If the child is type B, however, the mother will already have antibodies against that blood type and may remove the cells before her immune system can sense any additional foreign antigens.

Biology & Microbiology

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