Which of the following is true of patients with Hb H disease?
a. Have a severe anemia
b. Have three missing genes for a chain production
c. Have excess unpaired b chains present
d. Are of Northern European ethnicity
ANS: B
Hb H disease occurs when three genes are missing for a globin chain synthesis and an excess of b chains (b4), which is named Hb H, is present and easily detectable. A mild to moderate anemia is present. These individuals are primarily of Asian ethnicity.
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