A nurse is reviewing a patient's medications and realizes that gemfibrozil [Lopid] and warfarin [Coumadin] are to be administered concomitantly. Which effect will the nurse anticipate in this patient?

a. Increased levels of gemfibrozil
b. Decreased levels of gemfibrozil
c. Increased anticoagulant effects
d. Reduced anticoagulant effects


C
Gemfibrozil displaces warfarin from the plasma albumin, thereby increasing anticoagulant effects. The level of gemfibrozil will not be increased or decreased. The anticoagulation effects will not be reduced, because free-floating drug is present in the system; the dosage of warfarin may have to be reduced.

Nursing

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A client with multiple myeloma has been started on filgrastin (Neupogen) for treatment of neutropenia. The nurse identifies the drug is being effective when:

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Select the primary reason why the preferred route of administration for the corticosteroids in the treatment of chronic asthma and COPD is oral inhalation with metered-dose inhalers.

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Nursing