Which of the following would you expect to find with "O2 debt"? 1. Accentuated in diseases such as sepsis. 2. O2 demand exceeds O2 delivery. 3. O2 excess usage results in debt
a. 1, 2, and 3
b. 1 and 2 only
c. 2 only
d. 2 and 3 only
ANS: B
Decreases in O2 delivery result in an O2 "debt," when O2 demand exceeds O2 delivery. Under conditions of O2 debt, O2 consumption becomes dependent on O2 delivery (sloped line on Figure 12-19). This in turn leads to lactic acid accumulation and metabolic acidosis. In pathologic condi-tions such as septic shock and adult respiratory distress syndrome (dotted line in Figure 12-19), this critical point may occur at levels of O2 delivery considered normal.
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