The client has a fungal infection of the toenails, and receives oral terbinafine (Lamisil). The client asks the nurse how a pill will heal a nail infection. The nurse explains that terbinafine:
1. accumulates in nail beds and remains for several months.
2. breaks the cytoplasm in the fungal cell wall.
3. works by destroying toxins excreted by the fungi in the nails.
4. destroys circulating fungi in the blood.
Correct Answer: 1
Rationale 1: Lamisil accumulates in the toenail.
Rationale 2: Lamisil works by inhibiting ergosterol biosynthesis.
Rationale 3: Antifungals do not destroy toxins excreted by the fungi in the nails.
Rationale 4: Lamisil does not possess strong systemic antifungal properties.
Global Rationale: Lamisil is absorbed into the nail matrix and remains active for several months. It does not inhibit ergosterol biosynthesis, destroy toxins, or possess strong systemic properties.
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