What is the effect of an increased concentration of 2,3-BPG in the RBC?
a. Puts hemoglobin in the relaxed conformation
b. Shifts the oxygen dissociation curve to the left
c. Increases the affinity of hemoglobin for oxygen
d. Decreases the synthesis of globin chains
ANS: B
An increased concentration of 2,3-BPG shifts the oxygen dissociation curve to the left and decreases the affinity of hemoglobin for oxygen. It has no effect on the synthesis of globin chains.
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