What are the possible solutions to the problem of replicating the ends of linear prokaryotic DNA molecules?

What will be an ideal response?


Ans: There are several possible solutions to this problem. First, the single molecule may be circularized or polymerized so that free ends no longer exist. Second, a secondary structure, such as a hairpin, may form at the ends so that no free end exists. Third, the end of the molecule may be kept variable by adding additional copies of a repeating unit so that replication doesn't have to occur to the very end. Fourth, a protein may bind to the free ends to allow initiation of replication.

Biology & Microbiology

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