A child has been diagnosed with sickle-cell disease. The parents ask the nurse how their child got this disease. Which of the following is the best response to give the parents?
1. The mother and the father of the child have the sickle-cell trait.
2. The mother of the child has the trait, but the father doesn't.
3. The father of the child has the trait, but the mother doesn't.
4. The mother of the child has sickle-cell disease, but the father doesn't have the disease or the trait.
1
Rationale:
1. Sickle-cell disease is an autosomal recessive disorder; both parents must have the trait in order for a child to have 25% chance of having this disease.
2. Both parents must have the trait for the child to have a 25% chance of having this disease.
3. Both parents must have the trait for the child to have a 25% chance of having this disease.
4. Both parents must have the trait for the child to have a 25% chance of having this disease.
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