Which statement indicates that a client has understood instructions about cholestyramine?
1. "I will take this drug when I wake up in the morning."
2. "I should take this drug at least 1 hour before taking any other drugs."
3. "I will drink plenty of fluids while I am taking this drug."
4. "I should report to my doctor any increase in swelling of my ankles."
Correct Answer: 3
Rationale 1: Lipid-lowering drugs should be taken in the evening to take advantage of the diurnal pattern of greater cholesterol synthesis by the liver at night.
Rationale 2: Cholestyramine should be taken at least 4 hours before or 1 hour after other medications.
Rationale 3: An adequate fluid intake is necessary to prevent constipation in clients taking cholestyramine.
Rationale 4: Cholestyramine does not affect fluid balance by any mechanism.
Global Rationale: An adequate fluid intake is necessary to prevent constipation in clients taking cholestyramine. Lipid-lowering drugs should be taken in the evening to take advantage of the diurnal pattern of greater cholesterol synthesis by the liver at night. Cholestyramine should be taken at least 4 hours before or 1 hour after other medications. Cholestyramine does not affect fluid balance by any mechanism.
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