Describe the influence of rising PTH levels on bone, the small intestine, and the kidneys.
What will be an ideal response?
Parathyroid hormone (PTH) activates osteoclasts that break down the bone matrix, resulting in the release of Ca2+ and PO43- to the blood. PTH enhances intestinal absorption of Ca2+ indirectly by stimulating the kidneys to transform vitamin D to its active form, which is necessary for calcium absorption by the small intestine. PTH increases the reabsorption of calcium by the renal tubules, which simultaneously decreases phosphate ion reabsorption.
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