Which of the following characteristics of transcription initiation by ?70-containing polymerase holoenzymes is different than for ?54-containing polymerase holoenzymes?

A. The holoenzyme binds to its promoter to initially form a closed complex.
B. The formation of the closed complex is readily reversible.
C. The closed complex spontaneously converts to the open complex.
D. The opening of the DNA duplex is accompanied by energetically favorable conformational changes in the holoenzyme.
E. Initiation is primer-independent.


C

Biology & Microbiology

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