A teenager with bullous pemphigoid on the thighs asks, "What causes this blistering?" The best response by the nurse would be:

A) "Your body has developed antibodies against basement membrane proteins."
B) "You have been eating too much candy with large amounts of triglycerides."
C) "The contraction of your arrector pili muscles causes this."
D) "The lymph vessels are inflamed and responsible for this enlargement."


Ans: A
Feedback:
The basement membrane zone is often involved in skin disorders that cause bullae or blister formation. One of these disorders, bullous pemphigoid, is a blistering disease caused by antibodies against basement membrane proteins. The thighs and flexor tendons are most commonly affected. The disease is self-limited but chronic, and the person's general health is unaffected. The sympathetic nervous system controls the arrector pili (pilomotor) muscles that cause elevation of hairs on the skin. Contraction of these muscles tends to cause the skin to dimple, producing "goose bumps." The basal cells of the epidermis project into the papillary dermis, forming rete ridges. Lymph vessels and nerve tissue also are found in this layer.

Health & Biomechanics

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