Which factor would lead to the dilution of the drug furosemide (Lasix) in the newborn?
1. The higher proportion of fat to water dilutes water-soluble drugs.
2. There is no dilution of the drug in pediatric clients.
3. The lower proportion of water to fat dilutes water-soluble drugs.
4. The higher proportion of water to fat dilutes water-soluble drugs.
Correct Answer: 4
Rationale 1: The proportion of water to fat is higher in the newborn.
Rationale 2: The high water-to-fat ratio in the newborn dilutes furosemide.
Rationale 3: The proportion of water to fat is higher in the newborn.
Rationale 4: The newborn's weight is 80% water. The high proportion of water to fat dilutes water-soluble drugs.
Global Rationale: The newborn's weight is 80% water. The high proportion of water to fat dilutes water-soluble drugs. The proportion of water to fat is higher in the newborn. The high water-to-fat ratio in the newborn dilutes furosemide.
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