A patient is receiving treatment for Hodgkin lymphoma. Six weeks after cessation of the treatment, a cytogenetic analysis is performed. A structural aberration is found. Name the most probable aberration(s), and explain how these may occur
What will be an ideal response?
Answer: The most probable chromosomal aberrations are deletions of chromosomes 5 and 7. Also, 11q23 and 21q22 aberrations could be found in patients treated with chemotherapy. Aberrations in chromosomes 5 and 7 are related to treatment with alkylating agents. Aberrations in 11q23 and 21q22 are related to treatment with topoisomerase-II inhibitors.
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What will be an ideal response?