A pediatric nurse practitioner is aware that there are many knowledge gaps that still exist in the evidence base that underlies pediatric pharmacology. Many of these knowledge gaps are rooted in
A) a lack of scientific understanding of the anatomy and physiology of children and infants.
B) the historical lack of pediatric participation in the drug testing process.
C) the fact that research grants in pharmacology have traditionally specified adult participation.
D) assumptions that there are no physiological differences between adults and children.
B
Feedback:
Historically, researchers used only adults to test medications, and prescribers simply assumed that smaller doses would elicit the same results in smaller patients. The knowledge base surrounding anatomical and physiological differences between adults and children is substantial, and grant funding is not typically limited to adult participation.
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