Who is affected?
What will be an ideal response?
~1% (0.2% to 2.0%) ... female ? male
Comorbidity
Substance-related, Mood, Anxiety (panic, OCD)
Personality d/o (schizotypal, schizoid, paranoid) sometimes before onset of Scz
Periods of heightened risk
male: 18 to 25 female: 25 to 35
Gender differences
Men: poorer early social functioning
more negative symptoms
more withdrawal & passivity
poorer treatment response
Women: relatively good early social functioning
less often chronic
more hallucinations & paranoia
Course quite variable
Better or worse over time
Relapse potential high (12 month: 40%; 5 year: 75%)
Primary symptoms may change with age
Older adults: < positive, > negative symptoms
Life expectancy slightly less than average
Suicide attempts ~ 25%
(Successful) suicide rate ~10%
No typical pattern to timing
Prognosis relatively poor
Tend not to improve without treatment
Experience major life difficulties for years
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