A patient is being treated with warfarin (Coumadin) to prevent thrombus. The patient develops hyperuricemia, and the provider orders allopurinol (Zyloprim). The nurse will contact the provider to discuss _____ the _____ dose
a. increasing; allopurinol
b. increasing; warfarin
c. reducing; allopurinol
d. reducing; warfarin
ANS: D
Allopurinol can inhibit hepatic drug-metabolizing enzymes and thus delay the inactivation of other drugs. This is a particular concern in patients taking warfarin; therefore, the warfarin dose should be reduced when allopurinol is also used. It is not correct to increase the allopurinol dose, increase the warfarin dose, or reduce the allopurinol dose.
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