Angiotensin-converting enzyme (ACE) inhibitors such as captopril (Capoten) and enalapril (Vasotec) decrease peripheral vascular resistance and decrease blood pressure by the mechanism of
a. direct arterial vasodilation.
b. blocking the conversion of angiotensin I to angiotensin II.
c. increased fluid excretion at the loop of Henle in the renal tubules.
d. peripheral vasoconstriction and central vasodilation.
B
Angiotensin-converting enzyme (ACE) inhibitors produce vasodilation by blocking the conversion of angiotensin I to angiotensin II. Because angiotensin is a potent vasoconstrictor, limiting its production decreases peripheral vascular resistance. In contrast to the direct vasodilators and nifedipine, ACE inhibitors do not cause reflex tachycardia or induce sodium and water retention.
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