The nurse reviewing a medical record notes that high concentrations of methotrexate followed by leucovorin (citrovorum factor, folic acid) are being given to the client with cancer
The nurse correctly interprets that the reason for therapy with leucovorin is to: 1. Preserve normal cells.
2. Promote protein synthesis.
3. Promote medication excretion.
4. Hasten the effect of the methotrexate.
1
Rationale: The administration of leucovorin with methotrexate is known as leucovorin rescue. High concentrations of methotrexate cause harm and damage to normal cells. Leucovorin bypasses the metabolic block caused by methotrexate, thereby permitting normal cells to synthesize. Leucovorin rescue is potentially hazardous, because failure to administer leucovorin in the right dose at the right time can be fatal.
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