Substances most likely to pass across the blood–brain barrier have which of the following characteristics?
a. Low pH compared with body fluids c. Large particle size
b. Lipid solubility d. A close relation to toxic metabolites
B
Passage of substances across the blood–brain barrier is a function of particle size, lipid solubility, and protein-binding potential. Most drugs or compounds that are lipid soluble and stable at body pH rapidly cross the blood–brain barrier. The blood–brain barrier is also very permeable to water, oxygen, carbon dioxide, and glucose.
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